Introduction
What is PT-141
PT-141 is a synthetic peptide derived from the hormone alpha-melanocyte-stimulating hormone (α-MSH).
Unlike other sexual dysfunction treatments, which primarily focus on physiological responses, PT-141 primarily targets the brain to stimulate sexual desire and improve sexual function.
How Does PT-141 Work
PT-141 acts as a non-selective agonist for the melanocortin receptors in the brain, specifically targeting the melanocortin 4 receptor (MC4R).
By activating these receptors, PT-141 enhances sexual desire and arousal through neurochemical mechanisms.
By activating the MC4R in the hypothalamus, PT-141 increases the release of dopamine, a neurotransmitter associated with pleasure and reward.
This can enhance sexual motivation and arousal.
PT-141 also affects serotonergic signaling in the brain by inhibiting serotonin receptors, specifically the 5-HT2C receptor.
This modulation can result in increased sexual desire and arousal.
Furthermore, PT-141 enhances the release of nitric oxide (NO) in the genital area.
Nitric oxide acts as a vasodilator, relaxing and widening blood vessels, which leads to improved blood flow to the genital region.
This can contribute to erectile function in men and increased sensitivity and lubrication in women.
Methods of administration
PT-141 can be administered either nasally, using a nasal spray, or via subcutaneous injection.
The subcutaneous injection method is generally preferred due to its higher effectiveness.
When using the subcutaneous route, a smaller quantity of PT-141 is required to achieve the same effects.
Anecdotal evidence suggests that when PT-141 is administered through a nasal spray, the dosage may need to be increased up to three times compared to subcutaneous injection.
Dosing Guidelines
The typical dosage range for PT-141 is between 1 and 3 mg when administered subcutaneously.
It is usually taken approximately one hour before the intended sexual activity.
However, the onset of action and the resulting sexual enhancement effects can vary, and it may take anywhere from 1 to 6 hours to take effect.
It should not be used more than once within a 24-hour period.
It is recommended to use PT-141 no more than 8 times per month.
Exceeding the recommended frequency can increase the risk of side effects and may not improve efficacy.
If it’s your first-time using PT 141 I recommend starting with 500 mcg (0.5mg), see how you respond to the drug and maybe increase the dose next time you use it.
To achieve optimal arousal and libido enhancement effects for recreational purposes, the recommended dose falls within the range of 1 to 3 mg.
Generally, individuals who are in good health and do not experience significant libido issues may find that doses between 1 and 2 mg provide the desired benefits with minimal side effects.
Side Effects of PT-141
Reported side effects of PT-141 are generally mild and temporary.
These include transient nausea, temporary flushing that is mild in nature, mild headaches, and dizziness, as well as a temporary increase in blood pressure.
Personnal Experience
During the second week of my post cycle therapy (PCT) following a SARMs cycle involving RAD 140/S23 and HCG, I decided to use PT 141 due to my significantly low sex drive.
My aim was to see if PT 141 could help bring my nonexistent libido to a more reasonable level. I started with a dose of 0.5 mg and waited for approximately an hour, but I didn’t notice much effect.
Curious to see the outcome, I decided to take another 0.5 mg. Following each injection, I experienced mild nausea and hot flushes that lasted around 30 minutes.
Initially, I didn’t feel much else, but approximately 2-3 hours after the final injection, I experienced an intense increase in libido.
It reminded me of the heightened libido I experienced during my S23 and RAD 140 cycle when I was at the peak of my bulk.
PT 141 unquestionably works for me, but its effects seem to kick in around 3 hours after injection.
I find it to be an enjoyable drug and plan on using it occasionally for various kinky activities haha.
Where to find quality PT 141
These are the sources I recommend for quality PT 141
